Barsanti J A, Walser M, Hatheway C L, Bowen J M, Crowell W
J Am Vet Med Assoc. 1978 Apr 1;172(7):809-13.
Diffuse lower motor neuron dysfunction developed in a group of American Foxhounds while they were hunting. Of 19 dogs, 10 became weak and 9 became quadriplegic. Three of the quadriplegic dogs died before treatment could be instituted. The remaining quadriplegic dogs recovered after being given supportive treatment, with (4 dogs) or without (2 dogs) trivalent (types A, B, E) botulinal antitoxin. The 10 dogs that were weak recovered without treatment. A markedly decreased amplitude of evoked potentials and increased chronaxy were found by electromyographic examination of 2 of the quadriplegic dogs. A toxic substance that was neutralized by type C botulinal antitoxin in mouse inoculation tests was in the serum and feces of the most severly affected dog presented alive and in a fecal extract of another affected dog. In the one dog necropsied, neither gross nor histologic lesions were found in the central or peripheral nervous systems or in the skeletal musculature. The history, clinical signs, electromyographic findings, toxin neutralization tests in mice, and absence of histologic abnormalities in the neuromuscular system provided evidence for the diagnosis of C botulism.
一组美国猎狐犬在狩猎时出现了弥漫性下运动神经元功能障碍。19只狗中，10只变得虚弱，9只出现四肢瘫痪。3只四肢瘫痪的狗在开始治疗前死亡。其余四肢瘫痪的狗在接受支持性治疗后康复，其中4只使用了（A、B、E型）三价肉毒抗毒素，2只未使用。10只虚弱的狗未经治疗就康复了。对2只四肢瘫痪的狗进行肌电图检查发现，诱发电位幅度明显降低，时值增加。在存活的病情最严重的狗的血清和粪便以及另一只患病狗的粪便提取物中，发现了一种在小鼠接种试验中被C型肉毒抗毒素中和的有毒物质。在接受尸检的一只狗中，中枢或周围神经系统以及骨骼肌系统均未发现肉眼或组织学病变。病史、临床症状、肌电图检查结果、小鼠毒素中和试验以及神经肌肉系统无组织学异常，为诊断C型肉毒中毒提供了依据。
