Waziri R, Wilson R, Sherman A D
Br J Psychiatry. 1983 Jul;143:69-73. doi: 10.1192/bjp.143.1.69.
In a study of plasma amino acids in psychiatric patients, serine to cysteine (S/C) ratio was higher (S/C = 1.57 +/- 0.28) in 57 psychotics compared to 27 nonpsychotics (S/C = 1.06 +/- 0.23). This difference was highly significant at P less than 0.001. Psychotic patients were given a psychosis score (p score) of 1-4. The S/C ratios of individual patients were significantly correlated to their p scores (r = 0.65, P less than 0.001). S/C ratios were not related to diagnosis, age, sex, food intake and medications. When the initial S/C ratio and p scores of 22 patients were compared to their S/C ratio and p score at the time when they were improved and ready to be discharged, there was a concomitant fall both in S/C ratios and p scores suggesting the high S/C ratios may be indicative of a state rather than a trait characteristic. Our findings lead us to the conclusion that S/C ratios may provide a marker for the presence of psychosis and an index of its severity.
在一项针对精神病患者血浆氨基酸的研究中，57名精神病患者的丝氨酸与半胱氨酸（S/C）比值较高（S/C = 1.57 ± 0.28），而27名非精神病患者的该比值为（S/C = 1.06 ± 0.23）。这种差异在P < 0.001时具有高度显著性。给精神病患者评定了1至4分的精神病评分（p评分）。个体患者的S/C比值与他们的p评分显著相关（r = 0.65，P < 0.001）。S/C比值与诊断、年龄、性别、食物摄入量及药物治疗均无关。当比较22名患者初始时的S/C比值和p评分与病情好转准备出院时的S/C比值和p评分时，发现S/C比值和p评分同时下降，这表明高S/C比值可能指示一种状态而非特质特征。我们的研究结果使我们得出结论，S/C比值可能为精神病的存在提供一个标志物及其严重程度的一个指标。
