Miettinen T A, Alfthan G, Huttunen J K, Pikkarainen J, Naukkarinen V, Mattila S, Kumlin T
Br Med J (Clin Res Ed). 1983 Aug 20;287(6391):517-9. doi: 10.1136/bmj.287.6391.517.
A longitudinal case-control study of 33 patients with one or more risk factors for coronary heart disease and 64 controls showed that the serum selenium concentration (range 0.63-1.33 mumol/l (50-105 micrograms/l] was not associated with development of clinical manifestations of coronary heart disease during a follow up of five to seven years. The content of polyunsaturated fatty acids, especially eicosapentaenoic acid, in serum cholesterol esters and phospholipids was positively correlated with selenium concentration. As a low content of polyunsaturated fatty acids in serum lipids was an independent risk factor for coronary heart disease in these subjects it may be hypothesised that the high coronary risk in subjects with a very low serum selenium concentration (less than 0.57 mumol/l (less than 45 micrograms/l] might be due not to selenium deficiency but to the coexisting low concentrations of polyunsaturated fatty acids in serum.
一项针对33例患有一种或多种冠心病危险因素的患者及64例对照者的纵向病例对照研究表明，在5至7年的随访期间，血清硒浓度（范围为0.63 - 1.33微摩尔/升[50 - 105微克/升]）与冠心病临床表现的发展无关。血清胆固醇酯和磷脂中多不饱和脂肪酸的含量，尤其是二十碳五烯酸，与硒浓度呈正相关。由于血清脂质中多不饱和脂肪酸含量低是这些受试者患冠心病的一个独立危险因素，因此可以推测，血清硒浓度极低（低于0.57微摩尔/升[低于45微克/升]）的受试者冠心病风险高，可能不是由于硒缺乏，而是由于血清中同时存在低浓度的多不饱和脂肪酸。
