白喉棒状杆菌铁离子转运系统的初步表征
Initial characterization of the ferric iron transport system of Corynebacterium diphtheriae.
作者信息
Russell L M, Holmes R K
出版信息
J Bacteriol. 1983 Sep;155(3):1439-42. doi: 10.1128/jb.155.3.1439-1442.1983.
Abstract
Transport of ferric iron into Corynebacterium diphtheriae C7(beta) was shown to occur by a high-affinity, active transport system. Optimal rates were at pH 6.8 and 40 degrees C. Strong inhibition of uptake by carbonyl cyanide m-chlorophenylhydrazone was consistent with the electrochemical proton gradient as the major energy source for iron transport, and inhibition by Hg2+ indicated that sulfhydryl groups were also important. Evidence was obtained for stimulation of iron uptake at pH 8.0 by a dialyzable, extracellular factor present in conditioned medium from low-iron cultures of C. diphtheriae.
摘要
已证明三价铁进入白喉棒状杆菌C7（β）是通过一种高亲和力的主动运输系统进行的。最佳运输速率出现在pH 6.8和40℃条件下。羰基氰化物间氯苯腙对铁摄取的强烈抑制作用与电化学质子梯度作为铁运输的主要能量来源相一致，而Hg2+的抑制作用表明巯基也很重要。有证据表明，在pH 8.0时，来自白喉棒状杆菌低铁培养条件培养基中的一种可透析细胞外因子能刺激铁的摄取。
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