Lang S D, McKenzie D
Pathology. 1983 Apr;15(2):159-60. doi: 10.3109/00313028309084704.
The in vitro activity of azthreonam, a novel monocyclic beta-lactam antibiotic, was investigated for Gram negative urinary pathogens by determining the susceptibilities of 105 consecutive isolates from specimens submitted to the Auckland Hospital microbiology laboratory. All were sensitive or of intermediate sensitivity by disc diffusion testing. Minimum inhibitory concentrations (MICs) were 0.25 mg/l for 97 per cent of Enterobacteriaceae and ranged from 2-16 mg/l for Pseudomonas aeruginosa. Of antibiotics tested routinely in this laboratory only tobramycin showed comparable potency.
通过对提交至奥克兰医院微生物实验室的标本中连续分离出的105株菌株进行药敏试验，研究了新型单环β-内酰胺抗生素氨曲南对革兰氏阴性泌尿系统病原体的体外活性。通过纸片扩散试验，所有菌株均为敏感或中度敏感。97%的肠杆菌科细菌的最低抑菌浓度（MIC）为0.25mg/l，铜绿假单胞菌的MIC范围为2-16mg/l。在该实验室常规检测的抗生素中，只有妥布霉素显示出相当的效力。
