Mitsuma T, Nogimori T
Horm Metab Res. 1983 Aug;15(8):370-2. doi: 10.1055/s-2007-1018727.
Thyrotropin releasing hormone (TRH) is concentrated in the skin of Rana nigromacula. Its elution profile on Sephadex G-10 was identical to that of synthetic TRH. Insulin and noradrenaline stimulated TRH release from frog skin in a dose-related manner. The effects of insulin were not blocked by preincubation with phentolamine and they enhanced the noradrenaline effect. These data indicate that insulin stimulates directly TRH release from frog skin in other than the sympathetic pathway.
促甲状腺激素释放激素（TRH）集中在黑斑蛙的皮肤中。它在葡聚糖凝胶G - 10上的洗脱图谱与合成TRH的洗脱图谱相同。胰岛素和去甲肾上腺素以剂量相关的方式刺激青蛙皮肤释放TRH。胰岛素的作用不会被与酚妥拉明预孵育所阻断，并且它们增强了去甲肾上腺素的作用。这些数据表明，胰岛素通过交感神经途径以外的方式直接刺激青蛙皮肤释放TRH。
