Hernandez-Matheson I M, Frankowski R F, Held B
Trans R Soc Trop Med Hyg. 1983;77(3):405-11. doi: 10.1016/0035-9203(83)90174-8.
Pregnancy outcome and maternal morbidity were analysed in 302 pregnant women with positive Machado-Guerreiro Complement Fixation Test (MGCFT) for antibodies to Trypanosoma cruzi and 302 women with a negative MGCFT resident of Córdoba, Argentina. A comparison of positive and negative cases was employed to investigate the association between MGCFT reaction and pregnancy outcome assessed from abortion and perinatal infant mortality rates; similarly, the data were analysed for demographic and socio-economic factors, numbers of previous pregnancies (birth order) and maternal complications. A twofold increase in the risk of pregnancy loss associated with a positive MGCFT was found. The incidence of polyhydramnios and varicosities of the leg was significantly higher in the serologically reactive group.
对302名查加斯病补体结合试验（MGCFT）呈阳性（抗克鲁斯锥虫抗体）的孕妇以及302名居住在阿根廷科尔多瓦、MGCFT呈阴性的女性的妊娠结局和孕产妇发病率进行了分析。采用阳性和阴性病例对比的方法，根据流产率和围产期婴儿死亡率来研究MGCFT反应与妊娠结局之间的关联；同样，还分析了人口统计学和社会经济因素、既往妊娠次数（产次）以及孕产妇并发症的数据。结果发现，MGCFT呈阳性会使妊娠丢失风险增加两倍。羊水过多和腿部静脉曲张的发生率在血清学反应阳性组中显著更高。
