囊性纤维化患者铜绿假单胞菌感染联合抗生素和黏液溶解剂治疗的体外评估
In vitro assessment of combined antibiotic and mucolytic treatment for Pseudomonas aeruginosa infection in cystic fibrosis.
作者信息
Heaf D P, Webb G J, Matthew D J
出版信息
Arch Dis Child. 1983 Oct;58(10):824-6. doi: 10.1136/adc.58.10.824.
Abstract
The minimal inhibitory concentration of azlocillin for Pseudomonas aeruginosa is appreciably reduced when combined with the mucolytic agent mesna (Mistabron) because of an independent bacteriostatic effect of mesna. Bactericidal activity of azlocillin is unaltered by mesna. Mesna inhalations alone or combined with azlocillin may benefit cystic fibrosis patients with pseudomonas lung infections.
摘要
当阿洛西林与黏液溶解剂美司钠（Mistabron）联合使用时，由于美司钠具有独立的抑菌作用，其对铜绿假单胞菌的最低抑菌浓度会显著降低。美司钠不会改变阿洛西林的杀菌活性。单独使用美司钠吸入剂或与阿洛西林联合使用，可能会使患有铜绿假单胞菌肺部感染的囊性纤维化患者受益。
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本文引用的文献
1
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Br Med J. 1965 Jan 30;1(5430):317. doi: 10.1136/bmj.1.5430.317.
2
The effect of N-acetylcysteine on the viscosity of tracheobronchial secretions in cystic fibrosis of the pancreas.N-乙酰半胱氨酸对胰腺囊性纤维化患者气管支气管分泌物黏稠度的影响。
J Pediatr. 1963 Jan;62:31-5. doi: 10.1016/s0022-3476(63)80067-0.
3
Controlled trial of intermittent aerosol therapy with sodium 2-mercaptoethane sulphonate in cystic fibrosis.2-巯基乙烷磺酸钠间歇性雾化治疗囊性纤维化的对照试验
Thorax. 1980 Jan;35(1):42-6. doi: 10.1136/thx.35.1.42.
4
Aerosol carbenicillin and gentamicin treatment of Pseudomonas aeruginosa infection in patients with cystic fibrosis.雾化羧苄青霉素和庆大霉素治疗囊性纤维化患者的铜绿假单胞菌感染
Lancet. 1981 Nov 21;2(8256):1137-9. doi: 10.1016/s0140-6736(81)90588-2.
5
Outer membrane of Pseudomonas aeruginosa: heat- 2-mercaptoethanol-modifiable proteins.铜绿假单胞菌外膜：热 2 - 巯基乙醇可修饰蛋白。
J Bacteriol. 1979 Dec;140(3):902-10. doi: 10.1128/jb.140.3.902-910.1979.
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