Jacobowitz D M, Schulte H, Chrousos G P, Loriaux D L
Peptides. 1983 Jul-Aug;4(4):521-4. doi: 10.1016/0196-9781(83)90058-x.
The localization of human GRF1-44-immunoreactive neurons was studied in the rat brain. A dense accumulation of GRF-containing fibers was noted in the external layer of the median eminence. Cell bodies were observed in colchicine-treated rats. The most intensely fluorescent cluster of cells was contained in the arcuate nucleus. Other cells were seen on the base of the hypothalamus, within the median forebrain bundle, dorsal and ventral aspects of the ventromedial nucleus, zona incerta and dorsal part of the dorsomedial nucleus. These cells may influence the pulsatile release of pituitary growth hormone.
对大鼠脑中人类生长激素释放因子1 - 44免疫反应性神经元的定位进行了研究。在正中隆起外层发现了大量含生长激素释放因子的纤维聚集。在经秋水仙碱处理的大鼠中观察到了细胞体。最强烈荧光的细胞簇位于弓状核。在下丘脑底部、中脑前束内、腹内侧核的背侧和腹侧、未定带以及背内侧核的背侧部分也可见到其他细胞。这些细胞可能影响垂体生长激素的脉冲式释放。
