Stereochemistry of the hydrolysis products and their acetonides of two stereoisomeric benzo[a]pyrene 7,8-diol 9,10-epoxides.

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作者信息

Yang S K, McCourt D W, Gelboin H V, Miller J R, Roller P P

出版信息

J Am Chem Soc. 1977 Jul 20;99(15):5124-30. doi: 10.1021/ja00457a036.

DOI:10.1021/ja00457a036

PMID:874241

Abstract

摘要

相似文献

Stereochemistry of the hydrolysis products and their acetonides of two stereoisomeric benzo[a]pyrene 7,8-diol 9,10-epoxides.

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Synthesis and reactions of the highly mutagenic 7,8-diol 9,10-epoxides of the carcinogen benzo[a]pyrene.致癌物苯并[a]芘的高致突变性7,8-二醇9,10-环氧化物的合成与反应

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The mechanism of hydrolysis of the non-K-region benzo[a]pyrene diol epoxide r-7, t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene.非K区苯并[a]芘二醇环氧化物r-7，t-8-二羟基-t-9,10-环氧-7,8,9,10-四氢苯并[a]芘的水解机制。

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Regio- and stereoselectivity of various forms of purified cytochrome P-450 in the metabolism of benzo[a]pyrene and (-) trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene as shown by product formation and binding to DNA.通过产物形成以及与DNA的结合所显示的各种纯化形式的细胞色素P-450在苯并[a]芘和（-）反式-7,8-二羟基-7,8-二氢苯并[a]芘代谢中的区域选择性和立体选择性。

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