Behrendt W
Anaesthesist. 1983 Nov;32(11):548-53.
15 polytraumatized patients were treated within 5 posttraumatic days with reduced calorie and normal amino-acid supply (17 kcal/kg BW as carbohydrates and 1.0 g AA/kg BW). Changes in carbohydrate and protein metabolism were investigated. The fluid volume for parenteral nutrition did not exceed 2,000 ml/day. In spite of restricted carbohydrate dosage, we still needed 28IU of insulin daily to keep the blood glucose within a range of 8-10 mmol/l. Nitrogen balance ranged between -7 and -12 g per day. The unstable serum proteins transferrin, prealbumin, retinol-binding protein and the cholinesterases remained within normal values. Plasma AA showed the familiar pattern of the posttraumatic state with elevated levels of nearly all AA including BCAA although we were using a solution with a reduced BCAA content. The free fatty acids in serum reached values 40% above normal, the triglycerides remained within normal values. Infusion therapy can be considerably simplified by reducing carbohydrate dosage. The risk of intensifying existing metabolic disturbances declines. After five posttraumatic days a combined parenteral/enteral nutrition offering more calories was possible in 70% of our patients.
15例多发伤患者在创伤后5天内接受了低热量和正常氨基酸供应的治疗(碳水化合物为17千卡/千克体重,氨基酸为1.0克/千克体重)。研究了碳水化合物和蛋白质代谢的变化。肠外营养的液体量每天不超过2000毫升。尽管碳水化合物剂量受限,但我们每天仍需要28国际单位的胰岛素来将血糖维持在8 - 10毫摩尔/升的范围内。氮平衡每天在-7至-12克之间。不稳定的血清蛋白转铁蛋白、前白蛋白、视黄醇结合蛋白和胆碱酯酶仍在正常范围内。血浆氨基酸呈现出创伤后状态的常见模式,几乎所有氨基酸水平都升高,包括支链氨基酸,尽管我们使用的是支链氨基酸含量降低的溶液。血清中的游离脂肪酸达到比正常水平高40%的值,甘油三酯仍在正常范围内。通过减少碳水化合物剂量,输液治疗可以大大简化。加剧现有代谢紊乱的风险降低。创伤后5天后,70%的患者可以进行提供更多热量的肠外/肠内联合营养。