Behrendt W, Minale C, Giani G
Infusionsther Klin Ernahr. 1984 Dec;11(6):316-22.
After aorto-coronary bypass operations 40 patients were treated in a prospective-randomized study with 3 types of hypocaloric parenteral nutrition consisting of the same content of amino acids (75 g/day) but different amounts of carbohydrates: 120 g dextrose, 120 g or 200 g dextrose/fructose/xylitol (1:2:1) per day. 18 patients received only 75 g/day of dextrose (controls). The fluid volume for parenteral nutrition did not exceed 1500 ml/day. Changes in carbohydrate and protein metabolism were investigated. Because of restricted carbohydrate dosage, we needed no insulin to keep blood glucose within values of about 7-10 mmol/l. Postoperative serum insulin levels were significantly raised to 4-5 fold of preoperative values in all groups. Serum potassium concentrations remained normal under a supply of 80-100 mmol/day. Cumulative nitrogen balances were improved by about 48-58% in groups receiving parenteral nutrition despite a calorie/nitrogen ratio of 40:1 or 66:1 respectively. The expected beneficial effects on the concentrations of visceral serum proteins (transferrin, prealbumin, retinolbinding protein, cholinesterases) could not be found.
在进行主动脉冠状动脉搭桥手术后,对40例患者进行了一项前瞻性随机研究,给予3种低热量肠外营养治疗,这3种营养制剂氨基酸含量相同(75克/天),但碳水化合物含量不同:每天分别为120克葡萄糖、120克或200克葡萄糖/果糖/木糖醇(1:2:1)。18例患者仅接受75克/天的葡萄糖(对照组)。肠外营养的液体量每天不超过1500毫升。研究了碳水化合物和蛋白质代谢的变化。由于碳水化合物剂量受限,我们无需使用胰岛素就能将血糖维持在约7 - 10毫摩尔/升的水平。所有组术后血清胰岛素水平均显著升高至术前值的4 - 5倍。在每天供应80 - 100毫摩尔的情况下,血清钾浓度保持正常。尽管热量/氮比分别为40:1或66:1,但接受肠外营养的组累积氮平衡改善了约48% - 58%。未发现对内脏血清蛋白(转铁蛋白、前白蛋白、视黄醇结合蛋白、胆碱酯酶)浓度有预期的有益影响。