头孢他啶、其他β-内酰胺类药物及氨基糖苷类药物对铜绿假单胞菌的活性。
The activity of ceftazidime, other beta-lactams, and aminoglycosides against Pseudomonas aeruginosa.
作者信息
Rolston K V, Chandrasekar P H, LeFrock J L, Schell R F
出版信息
Chemotherapy. 1984;30(1):31-4. doi: 10.1159/000238241.
The inhibitory and bactericidal activities of ceftazidime, cefoperazone, ceftriaxone, piperacillin, and five aminoglycosides were determined against 50 tobramycin-susceptible and 25 multidrug-resistant isolates of Pseudomonas aeruginosa. Ceftazidime was the most active beta-lactam and tobramycin the most active aminoglycoside. The combination of piperacillin and tobramycin was synergistic in most cases. The combination of cephalosporin and tobramycin showed mostly addition or indifference, as did combination of two beta-lactams. No antagonism was observed.
测定了头孢他啶、头孢哌酮、头孢曲松、哌拉西林和五种氨基糖苷类药物对50株对妥布霉素敏感及25株耐多药铜绿假单胞菌分离株的抑制和杀菌活性。头孢他啶是活性最强的β-内酰胺类药物，妥布霉素是活性最强的氨基糖苷类药物。在大多数情况下，哌拉西林和妥布霉素组合具有协同作用。头孢菌素与妥布霉素的组合大多表现为相加或无作用，两种β-内酰胺类药物的组合也是如此。未观察到拮抗作用。
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