社区医院革兰氏阴性杆菌血培养分离株的抗生素敏感性

Antibiotic susceptibility of community hospital blood culture isolates of gram-negative bacilli.

作者信息

Gordon R C, Tack K J, Haddy R I, Fechner L, Wofford R

出版信息

Chemotherapy. 1984;30(1):40-3. doi: 10.1159/000238243.

PMID:6420120

Abstract

The comparative in vitro activity of amikacin, cefamandole, cefoperazone, cefotaxime, cefoxitin, cephalothin, chloramphenicol, moxalactam, piperacillin, ticarcillin and tobramycin against 170 community blood culture isolates of gram-negative bacilli was investigated using the quantitative plate dilution method. Results showed that amikacin, cefoperazone, cefotaxime, moxalactam, piperacillin and tobramycin were most active on a weight basis. Tobramycin and amikacin were quite active against Pseudomonas aeruginosa but one isolate showed an MIC of 50 micrograms/ml to both. The order of activity of the remaining drugs for P. aeruginosa was cefoperazone greater than moxalactam greater than cefotaxime and piperacillin greater than ticarcillin.

摘要

采用定量平板稀释法，研究了阿米卡星、头孢孟多、头孢哌酮、头孢噻肟、头孢西丁、头孢噻吩、氯霉素、拉氧头孢、哌拉西林、替卡西林和妥布霉素对170株社区获得性革兰氏阴性杆菌血培养分离株的体外比较活性。结果表明，按重量计算，阿米卡星、头孢哌酮、头孢噻肟、拉氧头孢、哌拉西林和妥布霉素活性最强。妥布霉素和阿米卡星对铜绿假单胞菌活性相当，但有1株分离株对二者的最低抑菌浓度均为50微克/毫升。其余药物对铜绿假单胞菌的活性顺序为：头孢哌酮＞拉氧头孢＞头孢噻肟和哌拉西林＞替卡西林。