骨髓前B细胞中λ基因激活的高频率。
High frequency of lambda gene activation in bone marrow pre-B cells.
作者信息
Nishikawa S I, Kina T, Gyotoku J I, Katsura Y
出版信息
J Exp Med. 1984 Feb 1;159(2):617-22. doi: 10.1084/jem.159.2.617.
Abstract
The frequency of lambda light chain (L) producing cells in immunoglobulin-producing cells that have been generated in vitro from bone marrow pre-B cells was investigated. The frequency of lambda-producing cells obtained in such a culture was three- to eightfold higher than that observed in the culture of mature spleen B cells. These results suggest that the activation of lambda gene at pre-B cell stage occurs far more frequently than the frequency presumed from the percentage of lambda-bearing cells in mature B cells.
摘要
研究了从骨髓前B细胞体外生成的免疫球蛋白产生细胞中产生λ轻链（L）的细胞频率。在这种培养物中获得的产生λ的细胞频率比在成熟脾B细胞培养物中观察到的频率高3至8倍。这些结果表明，前B细胞阶段λ基因的激活发生频率远高于从成熟B细胞中携带λ的细胞百分比推测的频率。
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本文引用的文献
1
kappa/lambda Shifts do not occur during maturation of murine B cells.κ/λ转换在小鼠B细胞成熟过程中不会发生。
J Immunol. 1981 Oct;127(4):1670-73.
2
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Influence of the nude and X-linked immune deficiency genes on expression of kappa and lambda light chains.裸基因和X连锁免疫缺陷基因对κ和λ轻链表达的影响。
Eur J Immunol. 1982 Dec;12(12):1033-9. doi: 10.1002/eji.1830121209.
4
Sequences of immunoglobulin lambda 1 genes in a lambda 1 defective mouse strain.λ1缺陷小鼠品系中免疫球蛋白λ1基因的序列
Nature. 1982 Jul 8;298(5870):184-7. doi: 10.1038/298184a0.
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Lambda chain expression at different stages of ontogeny in C57BL/6, BALB/c and SJL mice.C57BL/6、BALB/c和SJL小鼠个体发育不同阶段的λ链表达。
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Nature. 1981 Apr 2;290(5805):372-8. doi: 10.1038/290372a0.
8
Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells.人类免疫球蛋白κ轻链基因在产生λ链的B细胞中发生缺失或重排。
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