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骨髓前B细胞中λ基因激活的高频率。

High frequency of lambda gene activation in bone marrow pre-B cells.

作者信息

Nishikawa S I, Kina T, Gyotoku J I, Katsura Y

出版信息

J Exp Med. 1984 Feb 1;159(2):617-22. doi: 10.1084/jem.159.2.617.

DOI:10.1084/jem.159.2.617
PMID:6420503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187214/
Abstract

The frequency of lambda light chain (L) producing cells in immunoglobulin-producing cells that have been generated in vitro from bone marrow pre-B cells was investigated. The frequency of lambda-producing cells obtained in such a culture was three- to eightfold higher than that observed in the culture of mature spleen B cells. These results suggest that the activation of lambda gene at pre-B cell stage occurs far more frequently than the frequency presumed from the percentage of lambda-bearing cells in mature B cells.

摘要

研究了从骨髓前B细胞体外生成的免疫球蛋白产生细胞中产生λ轻链（L）的细胞频率。在这种培养物中获得的产生λ的细胞频率比在成熟脾B细胞培养物中观察到的频率高3至8倍。这些结果表明，前B细胞阶段λ基因的激活发生频率远高于从成熟B细胞中携带λ的细胞百分比推测的频率。

相似文献

1
High frequency of lambda gene activation in bone marrow pre-B cells.骨髓前B细胞中λ基因激活的高频率。
J Exp Med. 1984 Feb 1;159(2):617-22. doi: 10.1084/jem.159.2.617.
2
The level of lambda 1 light chain expression in the mouse reflects the probability of rearrangement of the relevant gene.小鼠中λ1轻链的表达水平反映了相关基因重排的概率。
Eur J Immunol. 1986 Jan;16(1):53-9. doi: 10.1002/eji.1830160111.
3
Block in development at the pre-B-II to immature B cell stage in mice without Ig kappa and Ig lambda light chain.在没有Igκ和Igλ轻链的小鼠中，B前体细胞II期至未成熟B细胞阶段的发育受阻。
J Immunol. 2003 Feb 1;170(3):1354-61. doi: 10.4049/jimmunol.170.3.1354.
4
The omega/lambda 5 surrogate immunoglobulin light chain is expressed on the surface of transitional B lymphocytes in murine bone marrow.ω/λ5替代免疫球蛋白轻链在小鼠骨髓中的过渡性B淋巴细胞表面表达。
J Exp Med. 1991 Jan 1;173(1):111-6. doi: 10.1084/jem.173.1.111.
5
Synthesis of lambda 1, lambda 2, and lambda 3 light chains by mouse spleen B cells.小鼠脾脏B细胞合成λ1、λ2和λ3轻链。
Eur J Immunol. 1982 Jul;12(7):552-7. doi: 10.1002/eji.1830120705.
6
Detection of normal B-cell precursors that give rise to colonies producing both kappa and lambda light immunoglobulin chains.检测可产生同时表达κ和λ轻链免疫球蛋白的集落的正常B细胞前体。
Proc Natl Acad Sci U S A. 1987 Jul;84(14):4989-93. doi: 10.1073/pnas.84.14.4989.
7
Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells.人类免疫球蛋白κ轻链基因在产生λ链的B细胞中发生缺失或重排。
Nature. 1981 Apr 2;290(5805):368-72. doi: 10.1038/290368a0.
8
The regulatory locus r lambda 1 affects the level of lambda 1 light chain synthesis in lipopolysaccharide-activated lymphocytes but not the frequency of lambda 1-positive B cell precursors.调控位点r lambda 1影响脂多糖激活的淋巴细胞中lambda 1轻链的合成水平，但不影响lambda 1阳性B细胞前体的频率。
Eur J Immunol. 1985 Jan;15(1):66-72. doi: 10.1002/eji.1830150113.
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Novel kappa light-chain gene rearrangements in mouse lambda light chain-producing B lymphocytes.小鼠产生λ轻链的B淋巴细胞中的新型κ轻链基因重排。
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10
Induction of proliferation and differentiation of murine B cells bearing surface Ig lambda by rat monoclonal antibody to lambda chain.用抗λ链大鼠单克隆抗体诱导带有表面Ig λ的小鼠B细胞增殖和分化。
Hybridoma. 1983;2(2):169-75. doi: 10.1089/hyb.1983.2.169.

引用本文的文献

1
Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappa.免疫球蛋白κ基因座中的基因靶向：高效产生表达λ链的B细胞，独立于免疫球蛋白κ基因重排。
EMBO J. 1993 Mar;12(3):811-20. doi: 10.1002/j.1460-2075.1993.tb05721.x.
2
Lupus/Sjögren's autoantibody specificities in sera with paraproteins.伴有副蛋白血症血清中的狼疮/干燥综合征自身抗体特异性
J Clin Invest. 1987 Jul;80(1):138-44. doi: 10.1172/JCI113039.
3
IgD/lambda plasmocytoma with immunoglobulin kappa light-chain genes in the germ-line configuration.具有种系构型免疫球蛋白κ轻链基因的IgD/λ浆细胞瘤
J Clin Immunol. 1988 Sep;8(5):407-13. doi: 10.1007/BF00917157.
4
Detection of normal B-cell precursors that give rise to colonies producing both kappa and lambda light immunoglobulin chains.检测可产生同时表达κ和λ轻链免疫球蛋白的集落的正常B细胞前体。
Proc Natl Acad Sci U S A. 1987 Jul;84(14):4989-93. doi: 10.1073/pnas.84.14.4989.

本文引用的文献

1
kappa/lambda Shifts do not occur during maturation of murine B cells.κ/λ转换在小鼠B细胞成熟过程中不会发生。
J Immunol. 1981 Oct;127(4):1670-73.
2
T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. I. Characterization of helper T cells.小鼠中T细胞对商陆丝裂原诱导的多克隆免疫球蛋白产生的调节。I. 辅助性T细胞的特性
Immunology. 1982 Jul;46(3):575-81.
3
Influence of the nude and X-linked immune deficiency genes on expression of kappa and lambda light chains.裸基因和X连锁免疫缺陷基因对κ和λ轻链表达的影响。
Eur J Immunol. 1982 Dec;12(12):1033-9. doi: 10.1002/eji.1830121209.
4
Sequences of immunoglobulin lambda 1 genes in a lambda 1 defective mouse strain.λ1缺陷小鼠品系中免疫球蛋白λ1基因的序列
Nature. 1982 Jul 8;298(5870):184-7. doi: 10.1038/298184a0.
5
Surface membrane kappa and lambda light chain expression on spleen cells of neonatal and maturing normal and immune-defective CBA/NB mice: the kappa:lambda ratio is constant.新生及成熟的正常和免疫缺陷CBA/NB小鼠脾细胞表面膜κ和λ轻链表达：κ:λ比值恒定。
J Immunol. 1981 Oct;127(4):1674-8.
6
Lambda chain expression at different stages of ontogeny in C57BL/6, BALB/c and SJL mice.C57BL/6、BALB/c和SJL小鼠个体发育不同阶段的λ链表达。
Eur J Immunol. 1981 Aug;11(8):618-25. doi: 10.1002/eji.1830110806.
7
Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression.异常重排对免疫球蛋白基因表达的等位基因排斥有显著贡献。
Nature. 1981 Apr 2;290(5805):372-8. doi: 10.1038/290372a0.
8
Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells.人类免疫球蛋白κ轻链基因在产生λ链的B细胞中发生缺失或重排。
Nature. 1981 Apr 2;290(5805):368-72. doi: 10.1038/290368a0.
9
Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain.产生单一功能性轻链的小鼠骨髓瘤细胞中多个轻链基因的活性
Cell. 1980 Aug;21(1):1-12. doi: 10.1016/0092-8674(80)90109-9.
10
Transcription of mouse kappa chain genes: implications for allelic exclusion.小鼠κ链基因的转录：对等位基因排斥的影响。
Proc Natl Acad Sci U S A. 1980 Apr;77(4):1937-41. doi: 10.1073/pnas.77.4.1937.