Shimura F, Shimura J, Shimazaki S, Hosoya N
J Nutr Sci Vitaminol (Tokyo). 1983 Oct;29(5):563-70. doi: 10.3177/jnsv.29.563.
The intestinal absorption of dinitrophenyl-lysine (DNP-lys) was studied with a special interest on the role of the immune system in the absorption of small molecules which are recognized as nonself. [3H]-DNP-lys was rapidly absorbed by ligated intestinal loops in situ via a saturable and unique route. When [3H]-DNP-lys was preincubated with the immune serum obtained from rats immunized with dinitrophenylated bovine serum albumin (DNP-BSA), the [3H]-DNP-lys absorption was depressed. The absorption of [3H]-DNP-lys in DNP-BSA-immunized rats was depressed compared to the control. The results obtained suggest that the immune system play a role in avoiding the absorption of small molecules with antigenicity.
研究了二硝基苯基赖氨酸（DNP-赖氨酸）的肠道吸收情况，特别关注免疫系统在识别为非自身的小分子吸收中的作用。[3H]-DNP-赖氨酸通过可饱和且独特的途径被原位结扎的肠袢迅速吸收。当[3H]-DNP-赖氨酸与用二硝基苯基化牛血清白蛋白（DNP-BSA）免疫的大鼠获得的免疫血清预孵育时，[3H]-DNP-赖氨酸的吸收受到抑制。与对照组相比，DNP-BSA免疫大鼠中[3H]-DNP-赖氨酸的吸收受到抑制。所得结果表明，免疫系统在避免具有抗原性的小分子吸收中发挥作用。
