来自紫外线转录图谱的证据表明，腺病毒2型晚期mRNA源自一个大型前体分子。
Evidence from UV transcription mapping that late adenovirus type 2 mRNA is derived from a large precursor molecule.
作者信息
Goldberg S, Nevins J, Darnell J E
出版信息
J Virol. 1978 Mar;25(3):806-10. doi: 10.1128/JVI.25.3.806-810.1978.
Abstract
The UV inactivation of labeling of various late adenovirus type 2 mRNA's is as great or greater than the inactivation of labeling of the same sequences that are present in a large primary RNA transcript in the cell nucleus. Thus, the large nuclear adenovirus type 2-specific RNA appears to be the obligatory precursor of cytoplasmic mRNA. The majority of the mRNA's derived from the large precursor apparently require the synthesis of the whole nuclear molecule. A UV-sensitive target necessary for proper processing of all the mRNA's may exist near the end of the transcription unit.
摘要
各种2型腺病毒晚期mRNA标记的紫外线失活程度与细胞核中大型初级RNA转录本中相同序列标记的失活程度一样大或更大。因此，大型细胞核2型腺病毒特异性RNA似乎是细胞质mRNA的必需前体。源自大型前体的大多数mRNA显然需要合成整个核分子。在转录单位末端附近可能存在一个对所有mRNA进行正确加工所必需的紫外线敏感靶点。
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