Aitken J M
Br Med J (Clin Res Ed). 1984 Feb 25;288(6417):597-601. doi: 10.1136/bmj.288.6417.597.
A prospective study of fractures of the femoral neck was conducted over 12 months in order to ascertain the relevance of generalised osteoporosis as determined by metacarpal morphometry. A series of some 200 women sustaining a fracture of the femoral neck after minor trauma had bone mass measurements similar to those of a control population of normal women, and 16% were not osteoporotic. A history of previous fractures was documented in one third of the women, but this was unrelated to the presence or severity of osteoporosis, although over half of the fractures had occurred within the previous four years. Trochanteric fractures were seen more commonly in severely osteoporotic women (p less than 0.005), whereas cervical fractures predominated in those who were not osteoporotic. These findings support the hypothesis that postural instability is the major determinant for femoral neck fracture and that generalised osteoporosis, rather than being a prerequisite for fracture, merely determines the type of fracture sustained.
为了确定由掌骨形态测量法测定的全身性骨质疏松症的相关性,我们进行了一项为期12个月的股骨颈骨折前瞻性研究。约200名在轻微创伤后发生股骨颈骨折的女性的一系列骨量测量结果与正常女性对照组相似,16%的女性没有骨质疏松症。三分之一的女性有既往骨折史,但这与骨质疏松症的存在或严重程度无关,尽管超过一半的骨折发生在过去四年内。转子间骨折在严重骨质疏松的女性中更常见(p小于0.005),而颈椎骨折在非骨质疏松女性中占主导地位。这些发现支持了以下假设:姿势不稳是股骨颈骨折的主要决定因素,全身性骨质疏松症不是骨折的先决条件,而仅仅决定了所发生骨折的类型。