Chen Y M, Lin E C
J Bacteriol. 1984 Mar;157(3):828-32. doi: 10.1128/jb.157.3.828-832.1984.
Anaerobic growth of Escherichia coli on L-fucose or L-rhamnose as the sole source of carbon and energy depends on the regeneration of NAD from NADH by disposing the intermediate L-lactaldehyde as L-1,2-propanediol. The two parallel pathways, with their own permeases and enzymes encoded by two widely separated gene clusters, appear to share a single enzyme that catalyzes the formation of L-1,2-propanediol. Although this oxidoreductase is encoded by a gene at the fuc locus, the enzyme is inducible by both L-fucose and L-rhamnose. The inducibility by L-rhamnose is controlled by a gene at the rha locus with no other known functions, since the aerobic growth rate on L-rhamnose remains normal. L-1,2-Propanediol oxidoreductase activity is inducible only anaerobically, and the effect of the two methylpentoses operates at different levels: L-fucose exerts its influence post-transcriptionally; L-rhamnose exerts its influence transcriptionally.
大肠杆菌以L-岩藻糖或L-鼠李糖作为唯一碳源和能源进行厌氧生长，这取决于通过将中间产物L-乳醛转化为L-1,2-丙二醇，从NADH再生NAD。这两条平行途径，具有各自的通透酶和由两个相距很远的基因簇编码的酶，似乎共享一种催化L-1,2-丙二醇形成的单一酶。尽管这种氧化还原酶由岩藻糖位点的一个基因编码，但该酶可被L-岩藻糖和L-鼠李糖诱导。L-鼠李糖的诱导作用由鼠李糖位点的一个基因控制，该基因没有其他已知功能，因为在L-鼠李糖上的有氧生长速率保持正常。L-1,2-丙二醇氧化还原酶活性仅在厌氧条件下可诱导，并且这两种甲基戊糖的作用在不同水平发挥：L-岩藻糖在转录后发挥作用；L-鼠李糖在转录水平发挥作用。
