Abdalla H I, Hart D M, Beastall G H
Br Med J (Clin Res Ed). 1984 Mar 10;288(6419):754-5. doi: 10.1136/bmj.288.6419.754.
Thyroid hormone state was assessed in a group of postmenopausal women who had received long term treatment with oestrogen. Serum concentrations of total thyroxine, triiodothyronine, and thyroxine binding globulin were raised compared with those in a control group given placebo; serum concentrations of thyroid stimulating hormone did not differ between the groups. Oestrogen treatment resulted in a significant decrease in the serum free thyroxine concentration and in the ratio of thyroxine to thyroxine binding globulin, which supports the view that oestrogen is the causative factor of the physiological reduction in free thyroid hormone during pregnancy.
对一组接受雌激素长期治疗的绝经后妇女的甲状腺激素状态进行了评估。与给予安慰剂的对照组相比，总甲状腺素、三碘甲状腺原氨酸和甲状腺素结合球蛋白的血清浓度升高；两组之间促甲状腺激素的血清浓度没有差异。雌激素治疗导致血清游离甲状腺素浓度以及甲状腺素与甲状腺素结合球蛋白的比率显著降低，这支持了雌激素是孕期游离甲状腺激素生理性降低的致病因素这一观点。
