Walker D H, Montenegro M R, Hegarty B C, Tringali G R
South Med J. 1984 Apr;77(4):447-9. doi: 10.1097/00007611-198404000-00009.
Because the killed Rickettsia vaccines have failed to provide protection against Rocky Mountain spotted fever, we approached the problem of protective immunity to Rickettsia rickettsii with a closely related, live, less pathogenic spotted fever Rickettsia. Guinea pigs vaccinated with R conorii produced antibodies to spotted fever group rickettsiae and did not have fever or other signs of illness after challenge with R rickettsii. A vaccine against Rocky Mountain spotted fever would be useful in some medical practices in the southeastern United States because of the life-threatening nature of the disease, including the possibility of a fulminant course and the frequent difficulty in diagnosis. Further studies should be pursued toward the goal of developing an effective vaccine against Rocky Mountain spotted fever.
由于灭活立克次体疫苗未能提供针对落基山斑疹热的保护作用，我们采用一种密切相关、活的、致病性较低的斑疹伤寒立克次体来研究针对立氏立克次体的保护性免疫问题。用康氏立克次体接种的豚鼠产生了针对斑疹伤寒群立克次体的抗体，在用立氏立克次体攻击后未出现发热或其他疾病迹象。鉴于落基山斑疹热疾病的危及生命性质，包括可能出现暴发性病程以及诊断时常遇到困难，一种针对落基山斑疹热的疫苗在美国东南部的一些医疗实践中会很有用。应朝着开发一种有效的落基山斑疹热疫苗这一目标开展进一步研究。
