落基山斑疹热疫苗保护活性的新检测方法。
New assay of protective activity of Rocky Mountain spotted fever vaccines.
作者信息
Anacker R L, Smith R F, Mann R E, Hamilton M A
出版信息
J Clin Microbiol. 1976 Sep;4(3):309-11. doi: 10.1128/jcm.4.3.309-311.1976.
Abstract
Areas under the fever curves of guinea pigs inoculated with Rocky Mountain spotted fever vaccine over a restricted dose range and infected with a standardized dose of Rickettsia rickettsii varied linearly with log10 dose of vaccine. A calculator was programmed to plot fever curves and calculate the vaccine dose that reduced the fever of infected animals by 50%.
摘要
在限定剂量范围内接种落基山斑疹热疫苗并感染标准化剂量立氏立克次体的豚鼠，其发热曲线下的面积与疫苗的log10剂量呈线性变化。已编程一个计算器来绘制发热曲线并计算使感染动物发热降低50%的疫苗剂量。
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本文引用的文献
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Factors affecting the growth of rickettsias of the spotted fever group in fertile hens' eggs.影响斑点热群立克次氏体在受精鸡蛋中生长的因素。
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Infect Immun. 1975 Jun;11(6):1203-9. doi: 10.1128/iai.11.6.1203-1209.1975.
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