O'Shea G M, Goosen M F, Sun A M
Biochim Biophys Acta. 1984 May 22;804(1):133-6. doi: 10.1016/0167-4889(84)90107-1.
Prolonged survival of islet allografts in streptozotocin-induced diabetic rats was achieved by encapsulating individual islets in protective, biocompatible alginate-polylysine-alginate membranes. A single intraperitoneal transplant of encapsulated islets reversed the diabetic state for up to 1 year. In contrast, a single injection of unencapsulated islets was effective for less than 2 weeks. The microencapsulation procedure, by protecting transplanted tissue from the components of the immune system, has great clinical potential in the treatment of diseases requiring organ transplantation, such as diabetes and liver disease.
通过将单个胰岛包裹在具有保护作用的生物相容性海藻酸盐-聚赖氨酸-海藻酸盐膜中，实现了链脲佐菌素诱导的糖尿病大鼠胰岛同种异体移植的长期存活。单次腹腔内移植包裹的胰岛可使糖尿病状态逆转长达1年。相比之下，单次注射未包裹的胰岛的效果持续不到2周。微囊化程序通过保护移植组织免受免疫系统成分的影响，在治疗需要器官移植的疾病（如糖尿病和肝病）方面具有巨大的临床潜力。
