El Solh N, Bismuth R, Allignet J, Fouace J M
Pathol Biol (Paris). 1984 May;32(5):362-8.
Resistance to pristinamycin (or virginiamycin) was first encountered in Staphylococcus aureus strains in 1975. These strains are usually multiresistant, in particular to streptogramin A components (SgA), macrolides, lincosamides and streptogramin B components (ML SgB ). Results of molecular analysis of 16 such strains, recently isolated, suggests that SgA resistance is not encoded by plasmid genes. Curing and mixed culture experiments allowed us to dissociate SgA from SgB resistance genes. Conversely, in a previous study on other strains, the same two resistance genes were shown to be carried by a single plasmid and could not be dissociated. Since 1981, a new type of pristinamycin -resistant S. aureus strains has been isolated. These strains are resistant to SgA and lincosamides but susceptible to macrolides and SgB . Eight such strains from 3 parisian hospitals have been studied. In mixed culture experiments, SgA resistance and penicillinase genes always transferred jointly. In some instances, these two determinants also cotransferred with genes encoding lincomycin, lincomycin and clindamycin, and/or aminoglycosides resistance.
1975年，在金黄色葡萄球菌菌株中首次发现对 pristinamycin（或维吉尼亚霉素）的耐药性。这些菌株通常具有多重耐药性，尤其是对链阳菌素A组分（SgA）、大环内酯类、林可酰胺类和链阳菌素B组分（ML SgB）耐药。对最近分离出的16株此类菌株进行分子分析的结果表明，SgA耐药性不是由质粒基因编码的。消除实验和混合培养实验使我们能够将SgA耐药基因与SgB耐药基因分开。相反，在之前对其他菌株的研究中，相同的两个耐药基因由单个质粒携带且无法分开。自1981年以来，已分离出一种新型的对pristinamycin耐药的金黄色葡萄球菌菌株。这些菌株对SgA和林可酰胺类耐药，但对大环内酯类和SgB敏感。对来自巴黎3家医院的8株此类菌株进行了研究。在混合培养实验中，SgA耐药性基因和青霉素酶基因总是共同转移。在某些情况下，这两个决定因素还与编码林可霉素、林可霉素和克林霉素以及/或氨基糖苷类耐药性的基因共同转移。
