Leclercq R, Carlier C, Duval J, Courvalin P
Antimicrob Agents Chemother. 1985 Sep;28(3):421-4. doi: 10.1128/AAC.28.3.421.
Staphylococcus haemolyticus BM4610 was resistant to high levels of lincomycin and susceptible to macrolides, clindamycin, and streptogramins. This resistance phenotype, not previously reported for a human clinical isolate, was due to inactivation of the antibiotic. The gene conferring resistance to lincomycin in strain BM4610 was carried by a 2.5-kilobase plasmid, pIP855, which was cloned in Escherichia coli. Plasmid pIP855 caused inactivation of both lincomycin and clindamycin in S. haemolyticus and in E. coli but conferred detectable resistance to lincomycin only in S. haemolyticus and to clindamycin only in E. coli.
溶血葡萄球菌BM4610对高水平的林可霉素耐药，而对大环内酯类、克林霉素和链阳菌素敏感。这种耐药表型此前在人类临床分离株中未见报道，其系抗生素失活所致。赋予BM4610菌株对林可霉素耐药性的基因由一个2.5千碱基的质粒pIP855携带，该质粒已在大肠杆菌中克隆。质粒pIP855可导致溶血葡萄球菌和大肠杆菌中的林可霉素和克林霉素失活，但仅使溶血葡萄球菌对林可霉素产生可检测到的耐药性，仅使大肠杆菌对克林霉素产生耐药性。
