Cefoperazone for urethritis due to penicillinase-producing Neisseria gonorrhoeae.

Thirty-two men infected with penicillinase-producing Neisseria gonorrhoeae were treated with a single intramuscular dose of 0.5 gm of cefoperazone. Of the 29 patients who were followed up, only two (7%) failed to recover; seven patients (26%) had postgonococcal urethritis. The MICs of cefoperazone were 0.03 microgram/ml (three strains), 0.06 microgram/ml (11), 0.12 microgram/ml (nine), 0.25 microgram/ml (one), and 0.5 microgram/ml (one).