Peterson G M, McLean S, Millingen K S
Epilepsia. 1984 Aug;25(4):412-7. doi: 10.1111/j.1528-1157.1984.tb03436.x.
Fifty-three hospital outpatients with epilepsy were randomly allocated to either a control or an intervention group. Patients in the intervention group were subjected to a combination of compliance-improving strategies: patient counselling, a special medication container, self-recording of medication intake and seizures, and mailed reminders to collect prescription refills and attend clinic appointments. Compliance with anticonvulsant therapy (as measured by plasma anticonvulsant levels and prescription refill frequencies), and seizure frequency, were evaluated in each patient prior to intervention and 6 months afterwards. Patient compliance and clinical control improved significantly in the intervention group patients. Seizure frequency was, on average, halved following intervention. Compliance and seizure frequency were unaltered in the control group. Intervention failed to improve clinic appointment keeping. Poor compliance with drug therapy commonly confounds the treatment of epilepsy. This study shows that compliance can be improved and seizure frequency lessened by strategies that are easily incorporated into the routine management of epileptic patients.
53名患有癫痫的门诊患者被随机分配到对照组或干预组。干预组的患者接受了一系列提高依从性的策略组合：患者咨询、特殊的药物容器、自行记录药物摄入和癫痫发作情况，以及邮寄提醒以收集处方续填和按时就诊。在干预前和干预6个月后，对每位患者的抗惊厥治疗依从性（通过血浆抗惊厥药物水平和处方续填频率衡量）和癫痫发作频率进行了评估。干预组患者的依从性和临床控制情况有显著改善。干预后，癫痫发作频率平均减半。对照组的依从性和癫痫发作频率没有变化。干预未能提高按时就诊率。药物治疗依从性差通常会干扰癫痫的治疗。这项研究表明，通过易于纳入癫痫患者常规管理的策略，可以提高依从性并降低癫痫发作频率。
