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支原体与淋巴细胞和吞噬细胞的相互作用：肺炎支原体释放的过氧化氢的作用。

Mycoplasma interaction with lymphocytes and phagocytes: role of hydrogen peroxide released from M. pneumoniae.

作者信息

Arai S, Munakata T, Kuwano K

出版信息

Yale J Biol Med. 1983 Sep-Dec;56(5-6):631-8.

PMID:6433574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2590513/
Abstract

Interferon (IFN) production by human peripheral lymphocytes stimulated with M. pneumoniae was investigated. The hydrogen peroxide released from M. pneumoniae was responsible for the induction of IFN from lymphocytes, since horseradish peroxidase inhibited the IFN production and abrogated the activity of IFN production in the supernatant of M. pneumoniae. The antiserum neutralizing IFN alpha and IFN beta failed to neutralize partially interferon produced by lymphocytes. Treatment either with pH 2.0 or antiserum neutralizing human IFN gamma resulted in a partial reduction of interferon. These results indicate that interferon produced by human lymphocytes stimulated with M. pneumoniae includes both types of IFN gamma and IFN beta.

摘要

研究了肺炎支原体刺激后人外周淋巴细胞产生干扰素（IFN）的情况。肺炎支原体释放的过氧化氢可诱导淋巴细胞产生IFN，因为辣根过氧化物酶可抑制IFN的产生，并消除肺炎支原体上清液中IFN的产生活性。中和IFNα和IFNβ的抗血清不能部分中和淋巴细胞产生的干扰素。用pH 2.0处理或用中和人IFNγ的抗血清处理，均可使干扰素部分减少。这些结果表明，肺炎支原体刺激人淋巴细胞产生的干扰素包括IFNγ和IFNβ两种类型。

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本文引用的文献

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Mycoplasma contamination in human tumor cell lines: effect on interferon induction and susceptibility to natural killing.人肿瘤细胞系中的支原体污染：对干扰素诱导及自然杀伤敏感性的影响
J Immunol. 1981 Jul;127(1):94-8.
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Activation of human T and non-T lymphocytes by sepharose-bound concanavalin A and the differential effect of macrophages.琼脂糖结合的伴刀豆球蛋白A对人T淋巴细胞和非T淋巴细胞的激活作用以及巨噬细胞的差异效应。
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Increase of peroxidation in carcinogenesis.致癌过程中过氧化作用的增强。
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Hemolysin and peroxide activity of Mycoplasma species.支原体的溶血素和过氧化物活性
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Proc Soc Exp Biol Med. 1974 Jun;146(2):613-8. doi: 10.3181/00379727-146-38158.

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