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新生儿补充肉碱与未补充肉碱时的总肉碱血药浓度及脂质利用情况。

Blood levels of total carnitine and lipid utilization with and without carnitine supplementation in newborn infants.

作者信息

Rubecz I, Sándor A, Hamar A, Mestyán J

出版信息

Acta Paediatr Hung. 1984;25(1-2):165-71.

PMID:6433944
Abstract

Postnatal changes of the plasma carnitine level were compared in orally and parenterally fed newborn infants. As expected, in contrast to the increasing plasma level of carnitine in infants fed with human milk, a gradual and significant fall was observed during parenteral feeding. Next, the effect of carnitine supplementation on the elimination rate of an Intralipid load was tested. The increased disappearance rate of triglycerides associated with the exogenously administered carnitine suggested an increased lipid utilization during the carnitine supplemented period of parenteral nutrition.

摘要

对经口喂养和胃肠外喂养的新生儿血浆肉碱水平的产后变化进行了比较。正如预期的那样,与母乳喂养婴儿血浆肉碱水平升高相反,胃肠外喂养期间观察到血浆肉碱水平逐渐且显著下降。接下来,测试了补充肉碱对脂肪乳剂负荷清除率的影响。外源性给予肉碱后甘油三酯清除率增加,这表明在补充肉碱的胃肠外营养期间脂质利用率提高。

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引用本文的文献

1
Carnitine supplementation of parenterally fed neonates.对经肠道外营养的新生儿补充肉碱。
Cochrane Database Syst Rev. 2000;2000(4):CD000950. doi: 10.1002/14651858.CD000950.
2
l-Carnitine. A preliminary review of its pharmacokinetics, and its therapeutic use in ischaemic cardiac disease and primary and secondary carnitine deficiencies in relationship to its role in fatty acid metabolism.左旋肉碱。对其药代动力学、在缺血性心脏病中的治疗应用以及与脂肪酸代谢作用相关的原发性和继发性肉碱缺乏症的初步综述。
Drugs. 1987 Jul;34(1):1-24. doi: 10.2165/00003495-198734010-00001.