French M A
Br Med J (Clin Res Ed). 1984 Sep 15;289(6446):646-7. doi: 10.1136/bmj.289.6446.646.
Four men presented with unexplained lymphadenopathy. Three had a history of recurrent respiratory infections for several years, and two had lymph node or hepatic granulomas. None was noted to have symptoms of immunodeficiency at the time of presentation. In one patient routine direct immunofluorescence study failed to detect IgA, and immunological investigations were therefore conducted in the rest. In all patients the findings were similar and characterised by a severe deficiency of IgA. In the absence of a more serious cause selective IgA deficiency may be enough to explain "idiopathic" lymphadenopathy.
四名男性出现不明原因的淋巴结病。其中三人有多年反复呼吸道感染史，两人有淋巴结或肝肉芽肿。在就诊时均未发现免疫缺陷症状。一名患者的常规直接免疫荧光研究未能检测到IgA，因此对其余患者进行了免疫学检查。所有患者的检查结果相似，其特征为严重的IgA缺乏。在没有更严重病因的情况下，选择性IgA缺乏可能足以解释“特发性”淋巴结病。
