Henderson K M, Franchimont P, Lecomte-Yerna M J, Hudson N, Ball K
J Endocrinol. 1984 Sep;102(3):305-9. doi: 10.1677/joe.0.1020305.
Four Romney ewes were actively immunized with a partially purified preparation of inhibin derived from bovine follicular fluid and their ovulation rates in four successive oestrous cycles were compared with those of four ewes receiving adjuvant alone. The ovulation rates of the ewes immunized with the inhibin preparation were significantly higher than those of the control ewes (2.06 +/- 0.16 (S.E.M.) vs 1.31 +/- 0.06 ovulations/ewe, n = 4). Plasma concentrations of FSH and LH, measured in blood samples taken three times a week for 11 weeks, during which time each ewe was immunized three times, were not significantly different between the two treatment groups. These results suggest that active immunization with inhibin-enriched follicular fluid may be a potential means of increasing fecundity in sheep.
用从牛卵泡液中提取的部分纯化的抑制素制剂对4只罗姆尼母羊进行主动免疫，并将它们在连续4个发情周期中的排卵率与4只仅接受佐剂的母羊的排卵率进行比较。用抑制素制剂免疫的母羊的排卵率显著高于对照母羊（分别为2.06±0.16（标准误）和1.31±0.06次排卵/母羊，n = 4）。在11周内每周采集3次血样测定促卵泡素（FSH）和促黄体素（LH）的血浆浓度，在此期间每只母羊免疫3次，两个治疗组之间无显著差异。这些结果表明，用富含抑制素的卵泡液进行主动免疫可能是提高绵羊繁殖力的一种潜在方法。
