Kao M, Ludwig H, Gosztonyi G
J Gen Virol. 1984 Oct;65 ( Pt 10):1845-9. doi: 10.1099/0022-1317-65-10-1845.
Borna disease virus has been adapted to the mouse, which required at least three passages in rat brains. Genetic specificity as studied with five inbred mouse strains was not evident. Newborn mice inoculated intracerebrally expressed antigen in neurons and remained persistently infected, with up to 10(7) infectious units per gram of brain tissue. Animals infected at different ages developed no disease and had high titres of antibodies.
博尔纳病病毒已适应小鼠，这需要在大鼠脑内至少传代三次。用五种近交系小鼠品系研究的遗传特异性并不明显。脑内接种的新生小鼠在神经元中表达抗原，并持续受到感染，每克脑组织中含有高达10⁷个感染单位。在不同年龄感染的动物未出现疾病，且抗体滴度很高。
