运动期间肺泡二氧化碳的变化率与通气控制
Rate of change of alveolar carbon dioxide and the control of ventilation during exercise.
作者信息
Allen C J, Jones N L
出版信息
J Physiol. 1984 Oct;355:1-9. doi: 10.1113/jphysiol.1984.sp015401.
The relationship between rate of change of alveolar PCO2 (delta PA, CO2/delta te), CO2 output (VCO2) and ventilation (VE) has been determined following a rapid increase in exercise intensity, to test the hypothesis that VE is related to VCO2 by a feed-forward control system responding to delta PA, CO2/delta te. There was a close relationship between delta PA, CO2/delta te and VCO2 (delta PA, CO2/delta te = 3.2 VCO2 + 0.85), but delta PA, CO2/delta te increased more rapidly than VCO2. Increases in mean inspiratory flow, an index of inspiratory drive, were more closely related to changes in delta PA, CO2/delta te than to changes in VCO2. Increases in VE during transient and steady-state conditions may be described by the equation: VE = 6.76 delta PA, CO2/delta te -3.50, a relationship which is consistent with a feed-forward control system.
在运动强度迅速增加后，已确定了肺泡二氧化碳分压变化率（δPA,CO2/δte）、二氧化碳排出量（VCO2）与通气量（VE）之间的关系，以检验以下假设：VE通过对δPA,CO2/δte作出反应的前馈控制系统与VCO2相关。δPA,CO2/δte与VCO2之间存在密切关系（δPA,CO2/δte = 3.2VCO2 + 0.85），但δPA,CO2/δte的增加比VCO2更快。吸气平均流量（吸气驱动的一个指标）的增加与δPA,CO2/δte的变化比与VCO2的变化关系更密切。在瞬态和稳态条件下VE的增加可用以下方程描述：VE = 6.76δPA,CO2/δte - 3.50，这种关系与前馈控制系统一致。
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