Gross J, Lee J, Stitzer M L
Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Pharmacol Biochem Behav. 1997 May-Jun;57(1-2):159-65. doi: 10.1016/s0091-3057(96)00309-7.
Nicotine exposure levels and subjective effects from smoking a de-nicotinized cigarette (Next) were examined under controlled conditions. Ten tobacco smokers smoked 20 puffs from their own brand (1.1 mg nicotine delivery, commercial cigarettes), a 0.7 mg nicotine "light" cigarette, or the Next de-nicotinized cigarette (< 0.1 mg nicotine) during independent experimental test sessions. The Next cigarette did not deliver and appreciable nicotine, did not elevate heart rate during smoking, and was rated as less satisfying than the smokers' own brand. Subjective ratings of cigarette carving and tobacco withdrawal symptoms increased during a 90 min post-smoking abstinence period. However, there were no measurable differences on these subjective ratings across the three cigarette test brands. It is concluded that nicotine can be removed from cigarettes without affecting the onset time course or intensity of cigarette cravings and other tobacco withdrawal symptoms in an acute abstinence model. Further studies to determine the subjective and physiological effects of nicotine-free cigarettes would contribute to a greater understanding of tobacco withdrawal and the processes involved in smoking maintenance.
在可控条件下，对吸一支去尼古丁香烟（Next）后的尼古丁暴露水平及主观效应进行了研究。10名吸烟者在独立的实验测试环节中，分别吸了20口他们自己品牌的香烟（尼古丁释放量为1.1毫克，商业香烟）、一支尼古丁含量为0.7毫克的“淡味”香烟，或Next去尼古丁香烟（尼古丁含量<0.1毫克）。Next香烟并未释放出可观的尼古丁，吸烟过程中也未使心率升高，且被评为不如吸烟者自己品牌的香烟令人满意。在吸烟后90分钟的禁欲期内，对香烟渴望和烟草戒断症状的主观评分有所增加。然而，在这三种香烟测试品牌之间，这些主观评分并无可测量的差异。得出的结论是，在急性禁欲模型中，可以从香烟中去除尼古丁，而不影响香烟渴望及其他烟草戒断症状的发作时间进程或强度。进一步研究无尼古丁香烟的主观和生理效应，将有助于更深入地了解烟草戒断及吸烟维持过程中涉及的机制。
