Shimizu J, Nomura S, Kuno H, Nakazawa T
Psychopharmacology (Berl). 1984;84(1):20-1. doi: 10.1007/BF00432017.
This experiment investigated the effect of imipramine on water wheel turning behavior in relation to the water temperature and the wheel load. It was shown that the higher the water temperature, the more the mice rotated the wheel, and the greater the wheel load, the less mice rotated it. However, these factors did not reduce the effect of imipramine, which increased the number of responses. It was suggested that the water wheel test shows promise as a screening test for antidepressants.
本实验研究了丙咪嗪对水轮转动行为的影响，该行为与水温及水轮负荷相关。结果表明，水温越高，小鼠转动水轮的次数越多；水轮负荷越大，小鼠转动水轮的次数越少。然而，这些因素并未降低丙咪嗪增加反应次数的作用效果。研究表明，水轮试验有望成为一种抗抑郁药筛选试验。
