Browne R G
Eur J Pharmacol. 1979 Oct 1;58(3):331-4. doi: 10.1016/0014-2999(79)90483-7.
A new "behavioral despair" test previously asserted to be selectively sensitive to antidepressant treatments was examined for specificity. The results of the present study demonstrate that, in addition to antidepressants, agents with anticholinergic properties such as scopolamine, danitracin, benactyzine, benztropin, clozapine and cyproheptadine also reduce immobility in this test. These results indicate that the swim test in mice cannot be considered selectively sensitive to antidepressants.
一种先前声称对抗抑郁治疗具有选择性敏感性的新“行为绝望”测试接受了特异性检验。本研究结果表明，除抗抑郁药外，具有抗胆碱能特性的药物，如东莨菪碱、达尼曲辛、苯那辛、苯海索、氯氮平和赛庚啶，在该测试中也能减少不动时间。这些结果表明，小鼠游泳测试不能被认为对抗抑郁药具有选择性敏感性。
