接受金硫代苹果酸钠二钠治疗的类风湿性关节炎患者的游离硫代苹果酸盐水平：与治疗临床结果的关系。
Free thiomalate levels in patients with rheumatoid arthritis treated with disodium aurothiomalate: relationship to clinical outcome of therapy.
作者信息
Rudge S R, Perrett D, Swannell A J
出版信息
Ann Rheum Dis. 1984 Oct;43(5):698-702. doi: 10.1136/ard.43.5.698.
Abstract
Sixteen patients with seropositive rheumatoid arthritis were treated with 20 mg disodium aurothiomalate (Myocrisin) weekly for six months. Disease activity was assessed before and after treatment. Plasma profiles and urinary excretion of free thiomalate were measured in all patients after the initial injection and again at six months in the 12 patients remaining on therapy. No difference was found in plasma levels or urinary excretion of free thiomalate between patients who responded to treatment or who developed toxic reactions and those who did not.
摘要
16例血清阳性类风湿关节炎患者接受了每周20mg金硫代苹果酸钠（米诺霉素）治疗，为期6个月。在治疗前后评估疾病活动度。在所有患者首次注射后以及继续治疗6个月的12例患者再次测量血浆中金硫代苹果酸的情况和游离硫代苹果酸的尿排泄量。在对治疗有反应或出现毒性反应的患者与无反应患者之间，游离硫代苹果酸的血浆水平或尿排泄量未发现差异。
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Free thiomalate levels in patients with rheumatoid arthritis treated with disodium aurothiomalate: relationship to clinical outcome of therapy.接受金硫代苹果酸钠二钠治疗的类风湿性关节炎患者的游离硫代苹果酸盐水平：与治疗临床结果的关系。
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本文引用的文献
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The determination of thiomalate in physiological fluids by high-performance liquid chromatography and electrochemical detection.
J Pharm Biomed Anal. 1983;1(2):205-10. doi: 10.1016/0731-7085(83)80028-4.
3
The assessment of disease activity in rheumatoid arthritis using a multivariate analysis.使用多变量分析评估类风湿性关节炎的疾病活动度。
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4
Pharmacokinetics of reduced D-penicillamine in patients with rheumatoid arthritis.
Arthritis Rheum. 1982 Jan;25(1):111-6. doi: 10.1002/art.1780250120.
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The metabolism and pharmacology of D-penicillamine in man.
J Rheumatol Suppl. 1981 Jan-Feb;7:41-50.
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