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类风湿关节炎患者肌肉注射金硫代苹果酸后硫代苹果酸部分的去向

Fate of the thiomalate part after intramuscular administration of aurothiomalate in rheumatoid arthritis.

作者信息

Jellum E, Munthe E

出版信息

Ann Rheum Dis. 1982 Aug;41(4):431-2. doi: 10.1136/ard.41.4.431.

DOI:10.1136/ard.41.4.431
PMID:6810769
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1000965/
Abstract

The excretory fate and plasma level of thiomalate were studied after intramuscular administration of auro-14C-thiomalate to 3 patients with rheumatoid arthritis. The gold and the thiomalate parts separated in vivo, and the free thiomalate was excreted in the urine, rapidly at first and then slowly. After one day about 60% of the 14C-label had been recovered in the urine. The plasma level also declined rapidly. The results are in complete agreement with those previously described in animal experiments.

摘要

对3例类风湿性关节炎患者肌肉注射金-14C-硫代苹果酸后，研究了硫代苹果酸的排泄情况和血浆水平。金和硫代苹果酸部分在体内分离，游离硫代苹果酸经尿液排泄，起初迅速，随后缓慢。一天后，约60%的14C标记物在尿液中被回收。血浆水平也迅速下降。这些结果与先前在动物实验中描述的结果完全一致。

相似文献

1
Fate of the thiomalate part after intramuscular administration of aurothiomalate in rheumatoid arthritis.类风湿关节炎患者肌肉注射金硫代苹果酸后硫代苹果酸部分的去向
Ann Rheum Dis. 1982 Aug;41(4):431-2. doi: 10.1136/ard.41.4.431.
2
Fate of the gold and the thiomalate part after intramuscular administration of aurothiomalate to mice.给小鼠肌肉注射硫代苹果酸金后，金和硫代苹果酸部分的去向。
Ann Rheum Dis. 1980 Apr;39(2):155-8. doi: 10.1136/ard.39.2.155.
3
Gold and thiol compounds in the treatment of rheumatoid arthritis: excretory fate and tissue distribution of thiomalate in relation to gold after administration of myocrisin (auro-thiomalate).金与硫醇化合物在类风湿性关节炎治疗中的应用：注射硫代苹果酸金钠（密里新）后硫代苹果酸与金相关的排泄去向及组织分布
Scand J Rheumatol Suppl. 1979(28):28-36.
4
Circulating thiomalate after administration of disodium aurothiomalate: impurity or active metabolite?金硫代苹果酸钠给药后循环中的硫代苹果酸盐：杂质还是活性代谢物？
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Free thiomalate in plasma and urine of patients receiving sodium aurothiomalate.接受金硫代苹果酸钠治疗的患者血浆和尿液中的游离硫代苹果酸盐。
Ann Rheum Dis. 1984 Feb;43(1):66-9. doi: 10.1136/ard.43.1.66.
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Intestinal resorption of gold salts used for treatment of rheumatoid arthritis.
Scand J Rheumatol. 1973;2(2):61-4. doi: 10.3109/03009747309098818.
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Free thiomalate levels in patients with rheumatoid arthritis treated with disodium aurothiomalate: relationship to clinical outcome of therapy.接受金硫代苹果酸钠二钠治疗的类风湿性关节炎患者的游离硫代苹果酸盐水平：与治疗临床结果的关系。
Ann Rheum Dis. 1984 Oct;43(5):698-702. doi: 10.1136/ard.43.5.698.
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[Reactions against sodium-auro-thiomalate in the treatment of rheumatoid arthritis].[硫代苹果酸金钠治疗类风湿关节炎的不良反应]
Z Rheumatol. 1979 Sep-Oct;38(9-10):381-4.
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Is gold necessary in so called chrysotherapy?在所谓的金疗法中黄金是必需的吗？
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A comparison of prednisolone with azathioprine and prednisolone with intramuscular gold in rheumatoid arthritis.泼尼松龙与硫唑嘌呤以及泼尼松龙与肌肉注射金制剂治疗类风湿关节炎的比较。
Clin Rheumatol. 1988 Jun;7(2):181-7. doi: 10.1007/BF02204452.

引用本文的文献

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Effect of gold sodium thiomalate and its thiomalate component on the in vitro expression of endothelial cell adhesion molecules.硫代苹果酸金钠及其硫代苹果酸成分对内皮细胞黏附分子体外表达的影响。
J Clin Invest. 1994 Nov;94(5):1864-71. doi: 10.1172/JCI117536.
2
Free thiomalate in plasma and urine of patients receiving sodium aurothiomalate.接受金硫代苹果酸钠治疗的患者血浆和尿液中的游离硫代苹果酸盐。
Ann Rheum Dis. 1984 Feb;43(1):66-9. doi: 10.1136/ard.43.1.66.
3
Progress in the characterization of gold drugs.金药物特性研究的进展。
Clin Rheumatol. 1984 Mar;3 Suppl 1:5-16. doi: 10.1007/BF03342617.
4
Binding of sodium aurothiomalate to human serum albumin in vitro at physiological conditions.硫代苹果酸金钠在生理条件下与人血清白蛋白的体外结合
Ann Rheum Dis. 1986 Sep;45(9):712-7. doi: 10.1136/ard.45.9.712.
5
Cultured human cells can acquire resistance to the antiproliferative effect of sodium aurothiomalate.培养的人类细胞可获得对金硫代苹果酸钠抗增殖作用的抗性。
Ann Rheum Dis. 1986 May;45(5):389-95. doi: 10.1136/ard.45.5.389.
6
Cultured human cells with high levels of gold-binding cytosolic metallothionein are not resistant to the growth inhibitory effect of sodium aurothiomalate.具有高水平结合金的胞质金属硫蛋白的培养人类细胞对硫代苹果酸金钠的生长抑制作用没有抗性。
Ann Rheum Dis. 1986 Feb;45(2):101-9. doi: 10.1136/ard.45.2.101.
7
Second-line anti-rheumatic drugs and free radical scavenging.二线抗风湿药物与自由基清除
Agents Actions. 1989 Jan;26(1-2):235-7. doi: 10.1007/BF02126623.
8
Thiol-containing compounds inhibit the production of monocyte/macrophage-derived angiogenic activity.含硫醇的化合物可抑制单核细胞/巨噬细胞衍生的血管生成活性的产生。
Agents Actions. 1991 Nov;34(3-4):350-7. doi: 10.1007/BF01988728.

本文引用的文献

1
Fate of the gold and the thiomalate part after intramuscular administration of aurothiomalate to mice.给小鼠肌肉注射硫代苹果酸金后，金和硫代苹果酸部分的去向。
Ann Rheum Dis. 1980 Apr;39(2):155-8. doi: 10.1136/ard.39.2.155.
2
Gold and thiol compounds in the treatment of rheumatoid arthritis: excretory fate and tissue distribution of thiomalate in relation to gold after administration of myocrisin (auro-thiomalate).金与硫醇化合物在类风湿性关节炎治疗中的应用：注射硫代苹果酸金钠（密里新）后硫代苹果酸与金相关的排泄去向及组织分布
Scand J Rheumatol Suppl. 1979(28):28-36.