Rudge S R, Perrett D, Swannell A J
Ann Rheum Dis. 1984 Feb;43(1):66-9. doi: 10.1136/ard.43.1.66.
Free thiomalate is measureable in the plasma and urine of patients with rheumatoid arthritis receiving sodium aurothiomalate (Myocrisin). Plasma concentrations and urinary excretion of free thiomalate were measured in 8 patients by high-performance liquid chromatography and electrochemical detection. After an initial intramuscular dose of 20 mg sodium aurothiomalate, free thiomalate was detected in plasma within 15 min, peak levels of up to 600 nmol/l occurring at 30 min. Plasma levels declined rapidly thereafter. During the first 24 h between 2 and 16% of the injected dose of aurothiomalate was recovered in the urine as free thiomalate, maximum excretion occurring during the first hour.
接受金硫代苹果酸钠（米诺索）治疗的类风湿性关节炎患者的血浆和尿液中可检测到游离硫代苹果酸盐。通过高效液相色谱法和电化学检测法对8例患者的游离硫代苹果酸盐的血浆浓度和尿排泄量进行了测定。在首次肌肉注射20mg金硫代苹果酸钠后，15分钟内血浆中检测到游离硫代苹果酸盐，30分钟时达到高达600nmol/l的峰值水平。此后血浆水平迅速下降。在最初的24小时内，2%至16%的注射剂量的金硫代苹果酸盐以游离硫代苹果酸盐的形式在尿液中回收，最大排泄量出现在第一小时。
