接受金硫代苹果酸钠治疗的患者血浆和尿液中的游离硫代苹果酸盐。
Free thiomalate in plasma and urine of patients receiving sodium aurothiomalate.
作者信息
Rudge S R, Perrett D, Swannell A J
出版信息
Ann Rheum Dis. 1984 Feb;43(1):66-9. doi: 10.1136/ard.43.1.66.
Abstract
Free thiomalate is measureable in the plasma and urine of patients with rheumatoid arthritis receiving sodium aurothiomalate (Myocrisin). Plasma concentrations and urinary excretion of free thiomalate were measured in 8 patients by high-performance liquid chromatography and electrochemical detection. After an initial intramuscular dose of 20 mg sodium aurothiomalate, free thiomalate was detected in plasma within 15 min, peak levels of up to 600 nmol/l occurring at 30 min. Plasma levels declined rapidly thereafter. During the first 24 h between 2 and 16% of the injected dose of aurothiomalate was recovered in the urine as free thiomalate, maximum excretion occurring during the first hour.
摘要
接受金硫代苹果酸钠（米诺索）治疗的类风湿性关节炎患者的血浆和尿液中可检测到游离硫代苹果酸盐。通过高效液相色谱法和电化学检测法对8例患者的游离硫代苹果酸盐的血浆浓度和尿排泄量进行了测定。在首次肌肉注射20mg金硫代苹果酸钠后，15分钟内血浆中检测到游离硫代苹果酸盐，30分钟时达到高达600nmol/l的峰值水平。此后血浆水平迅速下降。在最初的24小时内，2%至16%的注射剂量的金硫代苹果酸盐以游离硫代苹果酸盐的形式在尿液中回收，最大排泄量出现在第一小时。
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1958 Revision of diagnostic criteria for rheumatoid arthritis.1958年类风湿关节炎诊断标准修订版。
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Fate of the thiomalate part after intramuscular administration of aurothiomalate in rheumatoid arthritis.类风湿关节炎患者肌肉注射金硫代苹果酸后硫代苹果酸部分的去向
Ann Rheum Dis. 1982 Aug;41(4):431-2. doi: 10.1136/ard.41.4.431.
4
Fate of the gold and the thiomalate part after intramuscular administration of aurothiomalate to mice.给小鼠肌肉注射硫代苹果酸金后，金和硫代苹果酸部分的去向。
Ann Rheum Dis. 1980 Apr;39(2):155-8. doi: 10.1136/ard.39.2.155.
5
Is the mechanism of action during treatment of rheumatoid arthritis with penicillamine and gold thiomalate the same?青霉胺和硫代苹果酸金钠治疗类风湿关节炎时的作用机制相同吗？
Proc R Soc Med. 1977;70 Suppl 3(Suppl 3):136-9. doi: 10.1177/00359157770700S341.
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Capillary column gas chromatography--mass spectrometry in studies on rheumatoid arthritis.毛细管柱气相色谱-质谱联用技术在类风湿关节炎研究中的应用
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