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戊二醛和乙醛与核苷的反应位点。

Sites of reaction of glutaraldehyde and acetaldehyde with nucleosides.

作者信息

Hemminki K, Suni R

出版信息

Arch Toxicol. 1984 Sep;55(3):186-90. doi: 10.1007/BF00316126.

DOI:10.1007/BF00316126
PMID:6437377
Abstract

Glutaraldehyde, a dialdehyde, was reacted with ribonucleosides and deoxyribonucleosides and the products were purified by high-performance liquid chromatography (HPLC). Multiple reaction products were identified with cytosine- and purine-containing nucleosides. The products were labile, but spectroscopic evidence indicated that exocyclic amino groups were involved. Similar reactions were seen with acetaldehyde and butyraldehyde, monofunctional aldehydes. After reduction, one of the acetaldehyde-guanosine adducts was assigned the structure N2-ethylguanosine.

摘要

戊二醛，一种二醛，与核糖核苷和脱氧核糖核苷发生反应，产物通过高效液相色谱（HPLC）进行纯化。多种反应产物在含胞嘧啶和嘌呤的核苷中被鉴定出来。这些产物不稳定，但光谱证据表明涉及环外氨基。乙醛和丁醛（单官能醛）也出现了类似反应。还原后，其中一种乙醛 - 鸟苷加合物被确定为N2 - 乙基鸟苷的结构。

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本文引用的文献

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Isolation and identification of cross-links from formaldehyde-treated nucleic acids.从甲醛处理的核酸中分离和鉴定交联物。
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戊二醛暴露及其在医疗保健环境中的职业影响。
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