Zwahlen A, Waldvogel F A
Eur J Clin Microbiol. 1984 Oct;3(5):439-41. doi: 10.1007/BF02017367.
Two co-primary cases of schoolchildren with acute meningococcal disease due to infection with Neisseria meningitidis serogroup B are described. The first patient presented with septic shock and purpura fulminans, bacteremia greater than 10(5) organisms/ml blood, low C3 and factor B levels and an elevated level of C3d. The second patient had meningitis, negative blood cultures, normal levels of serum complement components but more than 10(4) organisms/ml in CSF. A comparison of the quantitative bacteriology data and complement profiles for these patients suggests that the degree of activation of complement during meningococcemia is directly related to the number of organisms in the blood. This association may determine the different clinical syndromes.
本文描述了两例因感染B群脑膜炎奈瑟菌而患急性脑膜炎球菌病的学龄儿童的共同主要病例。首例患者表现为感染性休克和暴发性紫癜，菌血症超过10⁵个菌/ml血液，C3和B因子水平降低，C3d水平升高。第二例患者患有脑膜炎，血培养阴性，血清补体成分水平正常，但脑脊液中菌量超过10⁴个菌/ml。对这些患者的定量细菌学数据和补体谱进行比较表明，脑膜炎球菌血症期间补体的激活程度与血液中的菌数直接相关。这种关联可能决定不同的临床综合征。
