Cornelison Ddw, Perdiguero Eusebio
Division of Biological Sciences and Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO, USA.
Cell Biology Group, Department of Experimental and Health Sciences (DCEXS), Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), 08003, Barcelona, Spain.
Methods Mol Biol. 2017;1556:3-19. doi: 10.1007/978-1-4939-6771-1_1.
Skeletal muscle stem cells, originally termed satellite cells for their position adjacent to differentiated muscle fibers, are absolutely required for the process of skeletal muscle repair and regeneration. In the last decade, satellite cells have become one of the most studied adult stem cell systems and have emerged as a standard model not only in the field of stem cell-driven tissue regeneration but also in stem cell dysfunction and aging. Here, we provide background in the field and discuss recent advances in our understanding of muscle stem cell function and dysfunction, particularly in the case of aging, and the potential involvement of muscle stem cells in genetic diseases such as the muscular dystrophies.
骨骼肌干细胞最初因其毗邻分化的肌纤维的位置而被称为卫星细胞，是骨骼肌修复和再生过程中绝对必需的。在过去十年中，卫星细胞已成为研究最多的成体干细胞系统之一，不仅在干细胞驱动的组织再生领域，而且在干细胞功能障碍和衰老方面都已成为一个标准模型。在这里，我们提供该领域的背景知识，并讨论我们对肌肉干细胞功能和功能障碍，特别是在衰老情况下的最新认识进展，以及肌肉干细胞在诸如肌肉萎缩症等遗传疾病中的潜在作用。
