Candela E, Camacho M V, Martínez-Torres C, Perdomo J, Mazzarri G, Acurero G, Layrisse M
J Nutr. 1984 Dec;114(12):2204-11. doi: 10.1093/jn/114.12.2204.
Studies on iron absorption from Na59Fe-EDTA in humans have shown that only a small proportion of the iron absorbed is excreted by the kidney, less than 1% of the dose administered. The pathway of Na55Fe-[2-14C]EDTA absorption and excretion when administered orally was studied in swine. A certain proportion (about 5%) of the 55Fe is split from the EDTA complex in the lumen of the gut, absorbed mainly from the pylorus and upper jejunum, transferred to plasma transferrin and then incorporated into the circulating hemoglobin. A small proportion of the iron absorbed, less than 1% of the dose administered, is excreted by the kidney, to a degree similar to that excreted by humans. The rest of the iron is eliminated in the feces, about 3% in a soluble form possibly still bound to EDTA and the greater part, about 92%, in an insoluble form. About 5% of the 14C is absorbed almost uniformly along the pyloric duodenal and jejunal mucosa, then transferred slowly to the plasma and excreted by the kidney within 48 hours. The rest of the 14C was excreted in the feces, about 80% in a soluble form and 20% in the insoluble fraction.
对人体中Na59Fe-EDTA铁吸收的研究表明，吸收的铁中只有一小部分通过肾脏排出，不到给药剂量的1%。在猪身上研究了口服Na55Fe-[2-14C]EDTA时的吸收和排泄途径。55Fe中有一定比例（约5%）在肠道腔内从EDTA复合物中分离出来，主要从幽门和空肠上段吸收，转移到血浆转铁蛋白中，然后掺入循环血红蛋白中。吸收的铁中有一小部分，不到给药剂量的1%，通过肾脏排出，排泄程度与人类相似。其余的铁通过粪便排出，约3%以可能仍与EDTA结合的可溶形式排出，大部分约92%以不溶形式排出。14C中有约5%几乎沿幽门十二指肠和空肠黏膜均匀吸收，然后缓慢转移到血浆中，并在48小时内通过肾脏排出。其余的14C通过粪便排出，约80%以可溶形式排出，20%以不溶部分排出。
