Adams J M, Glasheen W P, Severns M L
Ann Biomed Eng. 1984;12(1):1-13. doi: 10.1007/BF02410287.
We examined the tracer wash-in technique for measuring blood flow for a specific experimental model in which medullary chemoreceptor blood flow is estimated using carbon dioxide as the tracer. Using a mathematical model, we calculated the flow values that would be estimated when blood flow is a function of the tracer concentration, CO2. The estimate was compared with three indices of time-varying blood flow: the steady-state blood flow before and after the step change of CO2 and the time-average blood flow. Estimated blood flow was found to be most closely related to the final value of flow. Perfusion estimates from five pentobarbital anesthetized dogs were 102 ml/100 g/min (S.D. 35) at an average of PaCO2 of 60.7 Torr.
我们研究了用于测量特定实验模型中血流的示踪剂注入技术，在该模型中使用二氧化碳作为示踪剂来估计髓质化学感受器血流。通过数学模型，我们计算了当血流是示踪剂浓度（二氧化碳）的函数时所估计出的血流值。将该估计值与三个随时间变化的血流指标进行比较：二氧化碳阶跃变化前后的稳态血流以及时间平均血流。结果发现，估计的血流与血流最终值的关系最为密切。五只戊巴比妥麻醉犬在平均动脉血二氧化碳分压为60.7托时的灌注估计值为102毫升/100克/分钟（标准差35）。
