Weindler M, Kossmann B, Dick W, Mehrkens H H, Seeling W, Schwabe K
Reg Anaesth. 1984 Oct;7(4):125-30.
A controlled prospective randomized study was carried out to compare the action of 0.5% bupivacaine-CO2 and 0.5% bupivacaine-HCI both with and without diazepam premedication. Those patients given an epidural with 0.5% bupivacaine-CO2 and diazepam premedication showed both the briefest time to onset of action and the greatest degree of motor block. In contrast to the other three groups, none of these patients had missed segments. Despite the fact that no significant differences could be calculated, the difference in intensity of action observed in this investigation may well be of clinical relevance.
进行了一项对照前瞻性随机研究，以比较0.5%布比卡因 - 二氧化碳和0.5%布比卡因 - 盐酸盐在有和没有地西泮术前用药情况下的作用。那些接受0.5%布比卡因 - 二氧化碳硬膜外注射并用地西泮术前用药的患者，其起效时间最短，运动阻滞程度最大。与其他三组相比，这些患者均无节段缺失。尽管无法计算出显著差异，但本研究中观察到的作用强度差异很可能具有临床相关性。
