von Dorsche H H, Scheven C, Stiller K J, Timm D
Acta Histochem. 1984;75(2):199-203.
The insulin-content in islets of Langerhans on sand rats with disturbances of the carbon hydrate tolerance (reference-, impaired glucose tolerance-, and diabetic group) is measured cytophotometrically. In the IGT-group (impaired glucose tolerance) is a decrease of the insulin content in B-cells detectable. However in the diabetic group of sand rats is the insulin-content increased. This results demonstrate the stimulation of the B-cell function in the islets of Langerhans. The diabetes mellitus of sand rats is characterized by disturbed glucose tolerance hyperinsulinaemia, and elevated readiness to insulin secretion. That are characteristics of the human type-II-diabetes (insulin-independent). In conclusion, the sand rat is a biological model of the human type-II-diabetes (NIDDM).
采用细胞光度法测定了碳水化合物耐量紊乱的沙鼠（正常对照组、糖耐量受损组和糖尿病组）胰岛中的胰岛素含量。在糖耐量受损组中可检测到B细胞中的胰岛素含量降低。然而，沙鼠糖尿病组的胰岛素含量却增加了。这些结果表明胰岛中B细胞功能受到刺激。沙鼠的糖尿病特征为糖耐量紊乱、高胰岛素血症以及胰岛素分泌易感性升高。这些都是人类II型糖尿病（非胰岛素依赖型）的特征。总之，沙鼠是人类II型糖尿病（非胰岛素依赖型糖尿病）的生物学模型。
