Wilke B, Schmidt S, Klöting I, Schäfer H, Besch W, Zühlke H
Endokrinologie. 1979 Apr;74(1):73-80.
It was possible to induce different metabolic states in sand rats of our breeding colony or in newly caught Egyptian sand rats, respectively, by feeding a pellet diet or vegetable diet (green cabbage). Newly captured sand rats fed only on native food were used as reference group (group C). Plasma IRI-level and glucose in vivo and [3H]-leucine incorporation into proinsulin and insulin, insulin secretion and insulin content in vitro were investigated. Sand rats fed on pellet chow and ad libitum (group B) developed a hyperinsulinism and showed higher sensitivity of [3H]-leucine incorporation into proinsulin and insulin to glucose (maximal stimulation at 3 mM) and increased incorporation rates in vitro. Restriction of pellet food to 35-40 kcal/animal/day (group A) lead to changes of all parameters, which were investigated in the same direction as in group B, but to a much smaller extent. Newly captured sand rats, which were fed green cabbage for 4 to 6 weeks divided into two groups: One group (group D1) was comparable to the normal group (C) in IRI levels, glucose levels, glucose sensitivity and amount of [3H]-leucine incorporation. The other group (group D2) tended to group A. Marked changes in insulin content and insulin secretion of isolated pancreatic islets could not be found in any group.
通过分别给我们繁殖群体中的沙鼠或新捕获的埃及沙鼠喂食颗粒饲料或蔬菜饲料（绿甘蓝），有可能诱导出不同的代谢状态。仅以天然食物为食的新捕获沙鼠用作参照组（C组）。研究了体内血浆IRI水平和葡萄糖以及体外[3H] - 亮氨酸掺入胰岛素原和胰岛素的情况、胰岛素分泌和胰岛素含量。自由采食颗粒饲料的沙鼠（B组）出现了高胰岛素血症，并且显示出[3H] - 亮氨酸掺入胰岛素原和胰岛素对葡萄糖的敏感性更高（在3 mM时达到最大刺激）以及体外掺入率增加。将颗粒饲料限制为每只动物每天35 - 40千卡（A组）导致所有参数发生变化，这些参数的变化方向与B组相同，但程度要小得多。新捕获的沙鼠，喂食绿甘蓝4至6周，分为两组：一组（D1组）在IRI水平、葡萄糖水平、葡萄糖敏感性和[3H] - 亮氨酸掺入量方面与正常组（C组）相当。另一组（D2组）倾向于A组。在任何一组中均未发现分离的胰岛的胰岛素含量和胰岛素分泌有明显变化。
