André J L, Deschamps J P, Guéguen R
Arch Mal Coeur Vaiss. 1984 Oct;77(11):1278-82.
Familial aggregation of blood pressure (BP) was studied in 545 families, of which 370 included natural children only, 24 adopted children only and 175 both natural and adopted children. Mean values of four Automatic BP measurements (Dinamap 845) were converted into age (adult) or height (children) and sex adjusted scores. One comparison per family between parents and randomly chosen index children were made. A significant resemblance of blood pressure is observed between natural children and their parents: Systolic BP r = 0.24. Diastolic BP r = 0.29. N = 272 p less than 0.05. Adopted children did not have BP resemblances to the mean BP values of their parents but a significant resemblance was found between children and their mothers for a small sample (N = 46). Weight, heart rate, age and duration of cohabitation do not influence the results. A familial influence on BP can be detected in children. However, estimating the relative contribution of genetic and common environmental factors to BP correlations between family members is difficult. Nevertheless, the BP of children whose parents have high BP should be monitored.
对545个家庭的血压(BP)家族聚集性进行了研究,其中370个家庭只有亲生子女,24个家庭只有领养子女,175个家庭既有亲生子女又有领养子女。将四次自动血压测量(Dinamap 845)的平均值转换为年龄(成人)或身高(儿童)并进行性别调整得分。在每个家庭中,对父母和随机选择的指标儿童进行了一次比较。亲生子女与其父母之间观察到血压有显著相似性:收缩压r = 0.24,舒张压r = 0.29。N = 272,p < 0.05。领养子女与其父母的平均血压值没有血压相似性,但在一个小样本(N = 46)中发现儿童与其母亲之间有显著相似性。体重、心率、年龄和同居时间不影响结果。在儿童中可以检测到家族对血压的影响。然而,估计遗传和共同环境因素对家庭成员之间血压相关性的相对贡献是困难的。尽管如此,父母患有高血压的儿童的血压仍应受到监测。