Papapetropoulou M
Chemioterapia. 1984 Feb;3(1):63-6.
Two levels of gentamicin concentration (10 and 50 micrograms/ml were cross associated with two pH levels (pH 5 and 6) in a typical factorial arrangement of treatments. The time in hours required for the death of 50% (T50) of the inoculated microorganisms (E. coli and P. aeruginosa) was determined in urine of low osmolality (diabetes insipidus). Normal pH (pH 6) conserves its known favorable influence on gentamicin activity even at low osmolality. Interaction between pH and gentamicin concentration does exist at the 1% level but is antagonistic. The reasons are briefly discussed.
在典型的析因设计处理中，庆大霉素的两个浓度水平（10微克/毫升和50微克/毫升）与两个pH水平（pH 5和pH 6）交叉关联。在低渗尿（尿崩症）中测定接种微生物（大肠杆菌和铜绿假单胞菌）50%死亡所需的时间（T50，小时）。正常pH（pH 6）即使在低渗状态下也能保持其对庆大霉素活性已知的有利影响。pH和庆大霉素浓度之间在1%水平存在相互作用，但呈拮抗作用。对其原因进行了简要讨论。
