Thadepalli H, Bach V T, Webb D, Roy I
Chemotherapy. 1980;26(2):111-5. doi: 10.1159/000237891.
Pelvic inflammatory disease (PID) may be caused by anaerobic bacteria and or gonococcus and therefore the efficacy of two antibiotics, ampicillin (AMP) and spectinomycin (SPM) commonly used in this setting was examined against 370 isolates of anaerobic bacteria. At the highest therapeutically achievable serum levels, AMP (16 micrograms/ml) inhibited 83% of all anaerobes and 70% of Bacterioides fragilis, and SPM (128 micrograms/ml) inhibited 98% of all anaerobes and 95% of B. fragilis strains tested. It therefore appears that both AMP and SPM may have a place in the treatment of PID. In our study, greater percentage of anaerobes were susceptible to SPM than previously reported. We used the 'glove box' technique used for testing the susceptibility of anaerobes.
盆腔炎（PID）可能由厌氧菌和/或淋球菌引起，因此研究了常用于此情况的两种抗生素氨苄青霉素（AMP）和壮观霉素（SPM）对370株厌氧菌的疗效。在治疗可达到的最高血清水平时，AMP（16微克/毫升）抑制了83%的所有厌氧菌和70%的脆弱拟杆菌，而SPM（128微克/毫升）抑制了98%的所有厌氧菌和95%的受试脆弱拟杆菌菌株。因此，AMP和SPM似乎在PID的治疗中都有一席之地。在我们的研究中，厌氧菌对SPM敏感的百分比高于先前报道。我们使用了用于测试厌氧菌敏感性的“手套箱”技术。
